Product ID:TRYPSIN TYPE XII-S FROM BOVINE PANCREAS, T2271
MSDS Date:01/01/1999
FSC:6505
NIIN:00N093116
Status Code:A
MSDS Number: CJWJT

Emergency Phone: 314-771-5765

Info Phone: 314-771-5765

Cage: 21076

Telephone: 314-771-5765

Cage: 21076

(ORAL, RAT) >5 G/KG

CAS: 9002-07-7

RTECS: YN5075000

LD50 LC50 Mixture:SEE INGREDIENT
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:ACUTE EFFECTS: MAY BE HARMFUL BY
INHALATION, INGESTION OR SKIN ABSORPTION. CAUSES EYE AND SKIN
IRRITATION. MATERIAL IS IRRITATING TO MUCOUS MEMBRANES AND UPPER
RESPIRATORY TRACT. MAY CAUSE ALLERGIC RE SPIRATORY AND SKIN
REACTIONS. THE TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY
INVESTIGATED. ALSO, SEE TOXICOLOGICAL INFORMATION.
Effects of Overexposure:SEE HEALTH HAZARDS.

First Aid:EYES: IN CASE OF CONTACT, IMMEDIATELY FLUSH EYES WITH COPIOUS
AMOUNTS OF WATER FOR AT LEAST 15 MINUTES. SKIN: IN CASE OF CONTACT,
IMMEDIATELY WASH SKIN WITH SOAP AND COPIOUS AMOUNTS OF WATER.
INHALATI ON: IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE
ARTIFICIAL RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.
INGESTION: IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON
IS CONSCIO US. CALL A PHYSICIAN. REMOVE AND WASH CONTAMINATED
CLOTHING PROMPTLY.

Extinguishing Media:WATER SPRAY. CARBON DIOXIDE, DRY CHEMICAL POWDER OR
APPROPRIATE FOAM.
Fire Fighting Procedures:USE NIOSH APPROVED SCBA AND FULL PROTECTIVE
EQUIPMENT TO PREVENT CONTACT WITH SKIN AND EYES.

Spill Release Procedures:WEAR NIOSH APPROVED RESPIRATOR, CHEMICAL
SAFETY GOGGLES, RUBBER BOOTS AND HEAVY RUBBER GLOVES. SWEEP UP,
PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL. AVOID RAISING DUST.
VENTILATE AREA AND WASH SPILL S ITE AFTER MATERIAL PICKUP IS
COMPLETE.

Handling and Storage Precautions:DO NOT BREATHE DUST. DO NOT GET IN
EYES, ON SKIN, ON CLOTHING. AVOID PROLONGED OR REPEATED EXPOSURE.
WASH THOROUGHLY AFTER HANDLING. KEEP TIGHTLY CLOSED. STORE AWAY
FROM HEAT. STORE IN A COOL, DRY PLA CE.

Respiratory Protection:WEAR APPROPRIATE NIOSH APPROVED RESPIRATOR.
Ventilation:MECHANICAL EXHAUST REQUIRED.
Protective Gloves:CHEMICAL-RESISTANT GLOVES.
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES .
Other Protective Equipment:EYE WASH AND DELUGE SHOWER MEETING ANSI
DESIGN CRITERIA . WEAR OTHER PROTECTIVE CLOTHING.
Supplemental Safety and Health

Appearance and Odor:WHITE POWDER.

Stability Indicator/Materials to Avoid:YES
Hazardous Decomposition Products:NATURE OF DECOMPOSITION PRODUCTS NOT
KNOWN.

Waste Disposal Methods:DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE
SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN
AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE AND LOCAL
ENVIRONMENTAL REGULATIONS.

Toxicological Information:RTECS #: YN5075000. TRYPSIN. TOXICITY DATA:
ORL-RAT LD50: >5 G/KG NIIRDN -,744,1990. IPR-RAT LD50: >51 MG/KG
NIIRDN -,744,1990. IVN-RAT LD50: 36 MG/KG FATOAO 45(6),78,1982.
IMS-RAT LD50: 200 MG/KG NII RDN -,744,1990. ORL-MUS LD50: 1450
MG/KG NIIRDN -,744,1990. IPR-MUS LD50: 100 MG/KG FATOAO
45(6),78,1982. IVN-MUS LD50: 11100 UG/KG NIIRDN 6,523,1982. IMS-MUS
LD50: 105 MG/KG NIIRDN -,744,1990. IVN-RB T LD50: 2200 UG/KG NIIRDN
6,523,1982. ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL
SUBSTANCES (RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN
RTECS FOR COMPLETE INFORMATION.

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.

Ecological:DATA NOT YET AVAILABLE.

Transport Information:CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION
INFORMATION.

Federal Regulatory Information:REGULATORY INFO - EUROPEAN INFO:
HARMFUL. R 36/37/38 IRRITATING TO EYES, RESPIRATORY SYSTEM AND
SKIN. R 42 MAY CAUSE SENSITIZATION BY INHALATION. S 22 DO NOT
BREATHE DUST. S 24 AVOID CONTACT WITH SKIN . S 26 IN CASE OF
CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF WATER AND SEEK
MEDICAL ADVICE. S 36/37 WEAR SUITABLE PROTECTIVE CLOTHING AND
GLOVES. TLV AND SOURCE: RECOMMENDED CEILING LIMIT OF 0.06 MCG/M3.
REVIEWS, STANDARDS AND REGULATIONS: OEL=MAK. NOES 1983: HZD 83366;
NIS 1; TNF 72; NOS 4 ; TNE 820; TFE 628. EPA TSCA SECTION 8(B)
CHEMICAL INVENTORY.